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Research shows that low B12 levels are associated with increased body fat, disrupted fat processing and insulin resistance, highlighting its role in maintaining metabolic balance

Cell Death Differ (2014) 21(1):6978

Reactions were performed with 0.001 mg/ml DNA substrate Poly(dI-dC), 1 M radiolabelled S-adenosyl-L-[methyl-3H] methionine (SAM) co-substrate, and recombinant human DNMT1 enzyme

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Results A phenotypic screen identifies electrophilic compounds with senolytic activity To identify vulnerabilities of senescent cells, we took advantage of a library of electrophilic compounds (Methods) to conduct a senolytic screen (Fig