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When one-carbon metabolism is blocked along with VB6 supplementation, the tumor burden is significantly reduced in vivo (130) ( Table 2 )

Oxidative stress biomarkers (8-isoprostane) decreased by 35%

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For these six subjects, baseline GSH levels were all assigned the same value (the lowest measured GSH/Cr ratio value across all subjects and scans, divided by 2), in order to calculate the absolute change in GSH/Cr ratio relative to baseline

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