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49 therefore suggested an important role of the residue as a gatekeeper to modify the reactivity of reducing or alkylating agents

A., Poole, L

Journal of Biological Chemistry 263, 1720517208

Alternatively, strategies forcing the expression of MAT1A in liver cancer, instead of directly treating with SAMe, were shown to reduce HCC growth and angiogenesis, and increase apoptosis in in vitro and in vivo models [250]