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Studies have also found that as DR progresses, RMCs gradually start to undergo apoptosis, and the frequency of apoptosis is rapidly accelerated due to a decrease of protective cytokines such as BDNF and GDNF ( Under normal conditions, glial fibrillary acidic protein (GFAP) is primarily expressed by retinal astrocytes, but not by RMCs (Sanchez et al., 2022)