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[121] Age is also a contributing factor: elderly individuals are often achlorhydric due to reduced parietal cell function in the stomach, increasing their risk of vitamin B 12 deficiency

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doi:10.1007/s00296-013-2801-5

The compounds bind to entirely different receptors (beta-3 adrenergic vs GLP-1/GIP)

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The molecule was developed by the Australian pharmaceutical company Metabolic Pharmaceuticals (in collaboration with Monash University) and advanced through Phase I safety trials and a Phase IIb obesity efficacy trial enrolling approximately 900 participants in total