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Kurz T, Yamada KA, DaTorre SD, Corr PB

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207 A RANDOMIZED CONTROLLED TRIAL COMPARING SUSTAINED LOW EFFICIENCY DIALYSIS WITH CONTINUOUS RENAL REPLACEMENT THERAPY FOR SEPSIS-ASSOCIATED ACUTE KIDNEY INJURY IN CRITICALLY ILL PATIENTS WITH CIRRHOSIS (NCT04494542) Rakhi Maiwall 1 , Neha Chauhan 2 , Ashinikumar Kumar Hidam 2 , Sherin Thomas 2 , Chandani Bhagat 2 , Prashant Aggarwal 2 , Shivali Panwar 2 , Harsh Vardhan Tevethia 1 and Shiv Kumar Sarin 3 , (1)Institute of Liver and Biliary Sciences, New Delhi, (2)Institute of Liver and Biliary Sciences, (3)Ilbs Background: Continuous renal replacement therapy (CRRT) is the preferred mode of dialysis in critically ill hemodynamically unstable patients and in addition removes the inflammatory cytokines that accumulate in sepsis

The structure of NADP + similar to that of NAD + renders its binding to PARPs