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This may be one of the mechanisms underlying the effect of memantine in PD, as the K ATP channels on hippocampal neurons are composed of the same subunits as those on islet cells (Kir6.2 and SUR1) [186]

In addition, capsaicin (CAP), another gut microbiota metabolite, alleviates ventilator-induced lung injury by activating Sirtuin 3 (SIRT3) to inhibit ferroptosis and maintain mitochondrial redox homeostasis (129)

Baseline demographic and clinical data for the study participants are provided in Supplementary Table 1

The intercept is a measure of the overfit, Q2Y intercept value less than 0.05 indicates a valid model

doi: 10.3390/cancers18030393