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For instance, siBec1@PPN nanoparticles deliver siRNA against Beclin-1 to silence autophagy, reverse treatment resistance, and potentiate combined anticancer therapies [71]

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The tryptophan catabolite or kynurenine pathway in a major depressive episode with melancholia, psychotic features and suicidal behaviors: a systematic review and meta-analysis

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doi: 10.1182/blood-2011-04-348540 75 PorterDLHwangWTFreyNVLaceySFShawPALorenAWet al

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2) MCOLN1 (a lysosomal Ca 2+ exit channel that is a transcriptional target of TFEB) induces a high concentration of Ca 2+ microdomains near the lysosomal surface

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GG is associated with typical or higher GPX1 activity and stronger baseline antioxidant capacity, though supporting glutathione and selenium can still improve long-term resilience

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