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These reductions were most prominent at early time points but persisted through day 30

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Moreover, the interaction of -SNAP through this hydrophobic loop is critical for its canonical and non-canonical functions as mutations in this loop reduce by ~25 times the efficiency to disassemble SNAREs complexes 11 and negatively regulate SOCE 6

In such cases, patients tend to develop AD at an earlier age and are classified as early onset AD (EOAD) that occurs before 65 years of age and comprises around 5% of AD cases (Mendez, 2019)