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1E) and that NUPR1 has been suggested to fulfil a protective role in alveolar epithelial cells in the context of COPD 43 , we sought to investigate whether CS exposure may activate NUPR1 thus protecting from CS-induced cell death in phBECs

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Gaidamauskas E, Gyrup C, Boldt HB, Schack VR, Overgaard MT, Laursen LS, Oxvig C.IGF dependent modulation of IGF binding protein (IGFBP) proteolysis by pregnancy-associated plasma protein-A (PAPP-A): multiple PAPP-A-IGFBP interaction sites