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Rezaie, MD (Twitter: @srrezaie) Cite this article as: Cara Borelli DO, "E-Cigarette or Vaping Product Use-Associated Lung Injury (EVALI)", REBEL EM blog, April 23, 2020

6 How Nicotine Affects the Brain Nicotine activates cholinergic receptors in the brain that are usually activated by acetylcholine

Take, for example, something that came a little bit later than the original discoveries but certainly holds up much better: The Vase of the Smoking Monkey from the Classic period, roughly AD250 to AD900: In this photo, a spidermonkey, possibly a representation of a Mayan god, smokes what appears to be either a cigar or a cigarette