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Wang Y, Chen Y, Zhang J, Yang Y, Fleishman JS, Wang Y, et al

Imperatore, F

32 Behavioral assessments confirmed the development of PTSD-like symptoms, with mice exhibiting impaired fear extinction and retrieval in the contextual fear conditioning (CFC), as indicated by increased freezing behavior during retrieval sessions compared to controls (Fig

As shown in the score plots in Fig 4A and in Fig S5A, the greatest impact on the metabolic profile was found in Tbx1 +/ mice treated with vB12, revealed by the distance between this class (filled triangles) compared with the PBS-treated classes: WT (empty dots) and Tbx1 +/ (empty triangles) along the first component t (1) axis (x-axis)

Importantly, the protective actions of NAR and naringin were consistent across a range of experimental models, including oxidative, diet-induced, and replicative senescence, and spanned multiple organ systems

Cells were cultured in Eagles minimal essential medium modified by Dulbeccos medium (high-glucose DMEM