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The American Association of Public Health Physicians (AAPHP) suggests those who are unwilling to quit tobacco smoking or unable to quit with medical advice and pharmaceutical methods should consider other nicotine containing products such as electronic cigarettes and smokeless tobacco for long term use instead of smoking

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Doses may need to be higher in heavy smokers or heavy drinkers

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137]**PEER REVIEWED** Human Toxicity Values: In children 2 to 3 ml/kg is considered to be toxic