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Zhang T, Cheng JK, Hu YM

doi:10.1002/fsn3.1837

7.8 Biochemical studies and species specificity 1,2-Dibromoethane (75-100 mg/kg body weight) given by gavage to non-fasted Wistar rats induced DNA synthesis and cell division in the liver

This pathway can be inhibited by the cell-survival signaling pathways mitogen-activated protein kinase kinase (MEK)/extracellular signal-regulated kinase (ERK) and phosphoinositide 3-kinase (PI3K)/Akt (protein kinase B), which may protect the cells against the cytotoxic effects of VPA [210]

PMC 8065891

For doses exceeding 1.0 mL, either split into multiple injections at different sites or use multiple vials as needed