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A number of people have posted links about some of the below developments in the last post, and several people have also e-mailed me relevant links

ISSN 18716032;PAGE 15:Abstr 937 [ Mallet A, Mentre F, Steimer JL, Lokiec F (1988) Nonparametric maximum likelihood estimation for population pharmacokinetics, with application to cyclosporine

this is a maximum hypersensitivity reaction of the immune system with varying degrees of severity, but which can be acutely life-threatening (Bilwani et al., 2005)