hydroxyacyl glutathione hydrolase Glyoxalase 2: Towards a Broader View of the Second Player of the Glyoxalase System M-CSA Mechanism and Catalytic Site

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Most mammalian cells can tolerate an osmolality of 260 to 350 mOsm/kg

PFIC2 PFIC2 is caused by variants in the ABCB11 gene, which encodes the bile salt export pump (BSEP), the primary transporter of BAs from hepatocytes to the canalicular lumen

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A similar phenotype is seen in lenses lacking the transcription factor, AP-2

Some people experience mild discomfort, but it typically fades quickly