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Clinicians also use cisplatin off-label for other malignancies such as esophageal, gastric, hepatobiliary, breast, cervical, and more (Gold and Raja, 2023)

Next, single-nucleus RNA sequencing (sn-RNA-seq) data of ALI mice was applied to investigate the potential communications between hepatocytes and other types of liver cells deeply

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In addition, cKOt mice presented decreased production of NAD + , a key coenzyme of sirtuins including SIRT3, which is an important regulator of mitochondrial activity (43, 44)

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