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Blood Cancer J 4:e253, 2014

l4 stage animals were transferred to LB, DB or DB + 15 mM NAC plates and incubated at 20 C

Analysis of breast tumor tissues confirmed the increased level of DNA damage, most likely attributed to the formation of 4-hydroxy estradiol (4-OHE) mediated by cytochrome P450, which in turn can trigger the formation of ROS such as H 2 O 2 that are catalytically decomposed to OH radicals via the iron-Fenton reaction

Barreto R, Albuquerque-Junior RL, Pereira-Filho RN, Lima P, Nunes R, Barreto A, Junior WL, Camargo EA, Quintans-Junior LJ

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However, research shows that neurological and psychiatric symptoms can occur even with levels under 500 pg/mL (OLeary & Samman, 2010)