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doi: 10.1007/s10787-024-01510-2 129 TaguchiT.IkunoM.HondoM.ParajuliL

1 2 3 European Journal of Pharmacology

Non-canonical NF-B signaling in rheumatoid arthritis: Dr Jekyll and Mr Hyde

N Engl J Med 2005

When NRX is oxidized by NADPH oxidase 1 (NOX1)-derived H2O2 or lipid peroxide (ROOH), DVL is released and inhibits glycogen synthesis kinase 3 (GSK3) in the -catenin degradation complex, thereby stabilizing the -catenin in the cytoplasm and partially entering the nucleus to activate the target gene GPX2 by correlation with the TCF/LEF transcription factor family (Figure 2)