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Several observations, however, are undisputed: (i) corticosteroids are effective [91], (ii) superpotent topical corticosteroids applied in large quantities (initially 40 g/day) on the entire body are as effective as oral predniso(lo)ne at a starting dose of 0.5 mg/kg/day [91], (iii) predniso(lo)ne at a starting dose of 1.0 mg/kg/day is associated with a higher number of severe adverse events and increased mortality compared with predniso(lo)ne at a starting dose of 0.5 mg/kg/day [91], (iv) doxycycline 200 mg/day is effective, although significantly less than predniso(lo)ne at a starting dose of 0.5 mg/kg/day [92], (v) dapsone 1.5 mg/kg/day is effective and has a higher corticosteroid-sparing potential than azathioprine 1.52.5 mg/kg/day [93], and (vi) IVIG 2 g/kg body weight/day is effective [94]

References Jackson DA, Symons RH, Berg P: Biochemical method for inserting new genetic information into DNA of simian virus 40: circular SV40 DNA molecules containing lambda phage genes and the galactose operon of Escherichia coli

At present, there is still no high-quality randomized controlled trial confirming the efficacy of VLEKT in psoriasis, which highlights the need for more robust clinical evidence (195)

In addition, the metabolites obacunone and itaconate significantly reduced lung injury by inducing activation of the NRF2 pathway (108, 109)

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Ageeva-Kieferle A, Rudolf EE, Lindermayr C