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Deficient E-cadherin expression leads to the loss of epidermal melanocyte adhesion during situations of oxidative or mechanical stress.11 Furthermore, a relevant role of integrins and the Melanoma Inhibitory Activity (MIA) protein has been identified

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Elucidating this issue is complicated by multiple confounding factors, including population heterogeneity, medication use, dietary and lifestyle variations, disease staging, and inconsistencies in research methodologies