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2007 Apr;106(4):677-9

Adiposespecific lipin1 overexpression renders hepatic ferroptosis and exacerbates alcoholic steatohepatitis in mice

In addition, fumarate inhibits TET enzymes, which stimulate EMT, leading to cancer metastasis 131,132

The current results indicate that such approaches may be useful for targeting CD44 variant isoforms to modulate chemoresistance and suggest alternatives/additives to standard chemotherapy regimens