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10.1016/j.jhep.2018.06.008 39 Len-MimilaP.Villamil-RamrezH.LiX

In addition, UA enhances autophagy through mitophagy by promoting the nuclear translocation of transcription factor EB (TFEB), functions as a SERM, and reduces inflammatory responses 24, 27

SOS was diagnosed according to McDonlad criteria 14

[Para 29] 5

It has been demonstrated that keratinocytes as the key responding skin cells producing trigger factors, including LL37/nucleic acid complexes, lipid antigens, chemokines, and cytokines, as well as pathogens of viral or bacterial origin represent an important early upstream event in psoriasis [55]