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Role of Nrf2 in Oxidative Stress and Toxicity

It has been established that lung fibroblasts derived from COPD patients had certain defects, which impaired their ability to contract and remodel collagen gel

The receptor is then stored in azurophilic granules and secretory vesicles, ready for rapid deployment upon cellular activation

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doi: 10.1128/IAI.72.5.2494-2506.2004 264 RoierS.ZinglF

Such fine modulation of movement across the epithelium demands structural components that aid this process, such as transmembrane proteins including occludin, junctional adhesion molecules, and claudin protein family members that together maintain epithelial cell basolateral polarity (Shin et al