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Ethics declarations Ethics approval and consent to participate The study protocol and informed consent were approved by the Institutional Ethics Committee of: Shanghai Ninth Peoples Hospital Affiliated to Shanghai Jiao Tong University School of Medicine (SH9H-2024-T69-1) Shanghai Baoshan Hospital of Integrated Traditional Chinese and Western Medicine (2024K16) The First Affiliated Hospital of Xinjiang Medical University (K202501-03) Zhejiang University School of Medicine (2025-031) Huashan Hospital Affiliated to Fudan University (2025-701) Before signing the consent form, participants will be informed about interventions and potential AEs

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CHAC1 plays a significant role in enhancing chemotherapy sensitivity in prostate cancer cells by inducing ER stress and promoting ferroptosis