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long-term degradation, immune interactions, and redox perturbations of metal-based systems require systematic evaluation

Upon closer inspection, however, only a handful of genes were annotated with this KOG category (2132 genes, depending on the taxa), and most of these were not canonical immune response genes (for instance, no toll-like receptors, NF-KB-associated genes, immunoglobulins, tumor necrosis factors, or melanin pathway genes were among the 31 genes annotated with defense mechanisms in O