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Pheochromocytoma: This condition is suggested by increased urinary catecholamine excretion (i.e., vanillylmandelic acid and metanephrine) accompanied by headache, palpitations, and perspiration

Limited mitochondrial permeabilization is an early manifestation of palmitate-induced lipotoxicity in pancreatic -cells

These results align with a previous report on Nicotiana benthamiana callus treated with ZnONPs and chitosan-zinc oxide nano-bioformulation 75

This represents the homozygous dominant genotype in a standard Mendelian cross, resulting in an individual completely free of the disease mutation

On the other hand, transgene-free gene editing has been attempted through biolistic delivery of RNPs in immature wheat embryos and intact tobacco BY2 cells with 3-5% mutagenesis frequencies (Liang et al., 2017