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Discussion Acne is a chronic inflammatory skin disease with a high incidence, frequent recurrence, diverse clinical manifestations, and limited treatment efficacy

These side effects include: oropharyngeal candidiasis treated with topical clotrimazole (Bhatka & Choo, 2021) dysphonia (horseness) caused by a direct effect on vocal cords can be reduced by gargling water after each inhaled dose (Bhatka & Choo, 2021) hypothalamic pituitary-adrenal axis suppression ranges from 2.4% (low dose) to 21.5% (high dose) (Heffler et al, 2018) reduction in growth velocity (pediatric patients) corticosteroids can interfere with growth hormone secretion, osteoblast activity and other factors that can cause a average growth reduction of ~1 cm (Heffler et al, 2018) osteoporosis high doses of ICS used to treat severe asthma are at higher than normal risk for reduced bone mineral density and osteoporosis (Heffler et al, 2018) increased risk for type 2 diabetes use of ICS has been associated with a dose-dependent increase in risk for diabetes, up to ~34% with high dose use (Heffler et al, 2018) The risk of ICS-related adverse effects, which are most significant in patients with severe asthma who are taking higher doses of ICS may be reduced by judicious use of newer biologic agents which can result in the reduced need use of corticosteroids (Heffler et al, 2018

The authors reported the antioxidative effect of curcumin (decrease in MDA concentration, reduced production of RNS, reduction of TOS, and an increase in TAS) for each dose and form applied (solution/liposomes)

PLoS One 9 (8), e104401

90 KempkeS.LuytenP.ClaesS.Van WambekeP.BekaertP.GoossensL.et al

Omega-3 Fatty Acids Polyunsaturated fatty acids (PUFAs), especially the omega-3 variety, improves skin health and reduces acne by lowering inflammation and sebum production