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234 Inhibition of miR-449 elevated SIRT1 expression and inhibited acetylated p53 and Bax protein levels

For example, 21 days of treatment with a low-dose, oral delta-9-THC (1.5 mg, 3-times daily) did not affect dementia-related neuropsychiatric symptoms, although it was well tolerated with no clinically relevant side effects [103]

doi: 10.1074/jbc.M114.559187

Furthermore, effector genes GZMB , GNLY , GZMA , PRF1 , IL-2 , IFN as well as the master regulator of exhaustion TOX were significantly downregulated in rapamycin-treated CAR T products (Fig