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[PubMed] 24: Klein R, Meuer SM, Moss SE, Klein BE

Conversely, under conditions of oxidative stress these regulatory mechanisms become overwhelmed in the mitochondria, which leaves the organelle subject to massive damage by ROS and lipid peroxidation by-products (25)

With a high prevalence in developed countries and a significant increase in incidence in developing countries, it has grown to become a global burden 1