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l carnitine metformin

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Description

Specific knockdown of -synuclein by peptide-directed proteasome degradation rescued its associated neurotoxicity

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Burtscher J, Mallet RT, Pialoux V, Millet GP, Burtscher M

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doi: 10.1016/S0300-483X(03)00289-0 79 Yun-JeongKWilsonDM

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This design harnesses the elevated intracellular glutathione (GSH) levels in tumor cells to cleave the linker, releasing the active PROTAC for FOLR1-dependent ALK degradation

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In addition, AML cells overexpressing WT BCAT 1 had lower ROS, and the number of bone marrow markers (CD11b, CD14, CD68, and CD36) that marked cell differentiation on the cell surface was lower, suggesting the involvement of the BCAT 1 CXXC motif in ROS buffering and cell development in AML cells

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Cooperative NCoR/SMRT interactions establish a corepressor-based strategy for integration of inflammatory and anti-inflammatory signaling pathways

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