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"The importance of folate, vitamins B6 and B12 for the lowering of homocysteine concentrations for patients with recurrent pregnancy loss and MTHFR mutations"

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More recent work has confirmed the challenge of enrolling women in some therapeutic areas: in stroke clinical trials, for instance, women have been underrepresented even after incidence and prevalence of the disease is taken into account (Carcel, 2021), with highest underrepresentation reported in secondary prevention trials (10 percent in one study) (Strong et al., 2020)