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In a 6-month, randomized, double-masked, placebo-controlled study, ruboxistaurin enhanced skin microvascular blood flow at the distal calf, reduced sensory symptoms, improved the quality of life, and was well tolerated in DPN patients

Safety Profile in Research Models A notable feature of AOD 9604 research is the peptides clean profile in animal studies relative to full-length growth hormone

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The findings indicate that the effects of the medications needed to be monitored closely, the researchers said, stressing that changes could be made to help fight and potentially prevent these effects