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Most therapeutic research remains centered around experimental models of disease in rodents with limited work in the larger species, arguably narrowing the utility of these findings in horses on a clinical level

The activation of AMPK broadly suppresses proinflammatory signaling pathways, including the JAK-STAT, NF-B, C/EBP, CHOP, and HIF-1 pathways, which in turn inhibits the expansion and immunosuppressive function of myeloid-derived suppressor cells (MDSCs) 42

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These parameters indicate the maintenance of a more reducing redox environment in Plainsman which may contribute to its better drought tolerance due to the efficient removal of the excess of ROS (Considine and Foyer 2014a)

injections of vehicle or L2-Cmu (20 mg/kg) once per week and were monitored for interim survival to 24 mo of age ( n = 2438 per group) and sacrificed for blood, tissue, and histopathologic analysis

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