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At the FD location, a thicker epineurium and reduced echogenicity of the inner nerve structure were observed, consistent with Wallerian degeneration 3, 5

Taken together, these results suggest that Ssu72 induces adipogenesis and lipogenesis in white adipocytes by GSK3/-catenin axis under HFD conditions, contributing to adipose tissue expansion during diet-induced obesity

Dev Rev 24(2):189233

C: Group 3 retrograde nerve reinnervation with S-100 staining, showing evidence of the epineurium, perineurium, and endoneurium

Furthermore, HFD-induced microbiota dysbiosis disrupted the intestinal barrier, increasing gut pathogenic bacteria and circulating endotoxin, which disequilibrated the local microenvironment and caused inflammation in the lung (Chakradhar, 2017)

10.1016/j.devcel.2024.12.011 173 PerluigiM.Di DomenicoF.ButterfieldD