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Assessment of cryopreserved human hepatocytes as a model system to investigate sulfation and glucuronidation and to evaluate inhibitors of drug conjugation

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For C37 Fab molecules, only the VH/VL region bound to the E1E2 heterodimer in an identical manner, while the CH1/CL region exhibited varying degrees of swing relative to the VH/VL region, presumably to accommodate as many Fab molecules as possible at the 5f and 2f vertices