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In this context, the aim of the study was to test whether mitochondrial nutrients, CoQ 10 and LA, were able to modulate the oxidative status into different compartments (plasma and cells) in basal condition and following an oxidative insult in peripheral blood lymphocytes (PBL) exposed in vitro to H 2 O 2

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The Hoehn and Yahr (H&Y) scale scores decreased statistically significantly, while the United Parkinsons Disease Rating Scale (UPDRS) scores improved from the baseline level

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The two water molecules that are produced from hydrogen peroxide (H 2 O 2 ), in the reaction catalyzed by glutathione peroxide, can thus be traced back to NADPH, and can be expected to be deupleted, because NADPH in the mitochondria is derived from NADH via the mitochondrial enzyme NADH kinase (Zhu et al

doi:10.1016/s1522-8649(11)50016-2