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doi:10.1016/j.addbeh.2015.07.027

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Evidence-based : Ensuring clinicians understand the difference between serum B12 levels and clinically active B12 stores, and other suitable tests to determine deficiency as well as symptom resolution with sufficiently frequent treatment

In the brain, many PLP-dependent enzymes are involved in the metabolism of crucial amino acid or amine neurotransmitters such as dopamine, GABA, glycine, glutamate, and 5-hydroxytryptamine

This result supports that vitamin B6 may function as a source for brain therapeutics against excitotoxicity, since the release of glutamate in excess can result in neuronal damage (78)