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In the US, Vitamin B12 shots are available as a synthetic version of vitamin B12 (cyanocobalamin)

It is also important to note that taking large doses of folic acid can sometimes mask the hematological signs of a B12 deficiency, allowing neurological damage to progress unnoticed

NNMT inhibition increases cellular concentrations of both substrates that the enzyme would otherwise consume: SAM (the universal methyl donor) and nicotinamide (the NAD + salvage precursor)

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