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The algorithms can integrate experimental data, such as X-ray crystallography, NMR spectroscopy, 2D and 3D electron microscopy (EM), small-angle X-ray scattering (SAXS), mass spectrometry (MS), hydrogendeuterium exchange (HDX), mutations, sequence conservation and covariation, and statistical analysis of known structures

doi: 10.1373/clinchem.2004.035154