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In individuals with history of chronic hepatitis C, coffee intake was found to be associated with enhanced virologic reaction to antiviral drug therapy

Decreased RBC lifespan : This has been documented in mice (due to splenic macrophage erythrophagocytosis [Libregts et al 2011]) and cats with inflammation, although the mechanism was not elucidated in cats (Weiss and Kriehbiel 1983)