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The GH3 cells were maintained in F12-K medium containing 15% horse serum, 2.5% FBS and 1 penicillin/streptomycin solution

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While animal studies show a good safety profile, a theoretical risk involving its pro-angiogenic effects and potential cancer promotion is a point of consideration, though no evidence has supported this risk in practice

This ultimately contributed to the development of cagrilintide, which was specifically developed to function as a long-acting amylin receptor agonist

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