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Likewise, in experimental models of cerebral ischemia, sarcosine has shown neuroprotective activity in both in vivo and in vitro settings, further expanding its potential relevance beyond chronic neurodegeneration to acute brain injury (Pinto et al

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CTSD, although ubiquitously expressed in cells, exhibits high expression in the brain and decreases in its function are frequently suspected in mechanisms of neurodegeneration 179,185