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This primary configurational difference at the C-20 position makes the -methoxyacrylate group in speciogynine and paynantheine perpendicular to the molecules plane, whereas the substituent at C-20 in mitragynine is planar (see Figure 3)

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In another study it was found that after weight loss there is a rise in IGFBP-1 and IGFBP-2, both in children and adults [260, 261]