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Finally, we note that AlphaFold, which predicts single ranked structures for a protein sequence, is unable to address directly allosteric mechanisms, which are based on the populations of conformational states in the ensembles

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2 Essential functions of oligodendrocytes and myelination 2.1 The basic functions of oligodendrocytes 2.1.1 Oligodendrocytes form myelin sheath Oligodendrocytes are glial cells in the CNS, a class of multifunctional neuroglia primarily located in the white matter of the CNS ( 2.1.2 Oligodendrocytes provide metabolic support Oligodendrocytes also deliver metabolic support to axons ( 2.1.3 Oligodendrocytes regulate neural plasticity Oligodendrocytes play a crucial role in modulating neural plasticity through dynamic signaling interactions, thereby preserving the functional integrity of brain networks and supporting neurodevelopment and cerebral homeostasis ( Oligodendrocytes play a pivotal role in enhancing synaptic plasticity through the secretion of neurotrophic factors, such as brain-derived neurotrophic factor (BDNF), and metabolic substrates like lactate, thereby directly influencing neuronal survival and functional activity ( 2.2 Basic functions of myelin sheath The myelin sheath is rich in lipids (70%) and proteins (30%), including myelin basic protein (MBP) and proteolipid protein (PLP)