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aureus is characterized by a lipid peroxidation mechanism where AA is oxidized into reactive electrophiles, which elicit toxicity by modifying the macromolecules of S

46 MissallT

The Mg 2+ -bound enzyme is catalytically active, while a low Mg 2+ state may permit small molecule inhibition at the allosteric site (Extended Data Fig

Preclinical acute toxicity is low, with reported rodent LD50 values well above any human-equivalent research dose

Kassar-Duchossoy L, et al

However, as the development of multi-specific protein therapeutics becomes more widespread, the potential for immune complex formation and consequent immunogenicity must be considered, as the latter can lead to both loss of pharmacodynamic activity and safety concerns