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589 DN and DPN share a reciprocal relationship, both arising from prolonged hyperglycemia and common pathophysiological mechanisms, such as oxidative stress, inflammation, and endothelial dysfunction

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High doses of ANP and BNP exacerbate lipolysis in humans and the lipolytic effect of BNP is associated with cardiac triglyceride content in pigs

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Renal Effects In the kidney, prostaglandins, produced by both COX-1 and COX-2, are important regulators of sodium and water reabsorption through PGE2 and of renal function and hemodynamics via PGI2 in response to vasoconstrictive factors (e.g., endothelin-1, a factor that increases peripheral vascular resistance) and through effects on the renin-angiotensin system