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Skin begins to wrinkle Smoking contributes to the degradation of collagen and elastic fibers in the skin, suggesting an imbalance between biosynthesis and the destruction of dermal connective tissue, according to research, leading to accelerated aging of the skin

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This scoping review may identify areas that could benefit from subsequent systematic review and/or metanalysis We have added a sentence to the second paragraph of the Stage 2 section of our manuscript describing our rationale for including all epilepsy types and tobacco use patterns