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GPCRs that are agonist-activated promote the synthesis of guanine triphosphate (GTP), which when bound to the G-protein causes the Ga and Gbc subunits to separate, which in turn can activate signaling proteins downstream [52]

PMID: 30077201 Vukojevic J, et al

References Mechanism of Action 1-6 Sermorelin acts as an agonist at the GHRH receptor in the anterior pituitary, stimulating somatotroph cells to increase the synthesis and pulsatile release of endogenous growth hormone (GH)

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Esmann, S

The primary effect will be loss of the metabolic rate enhancement, though tirzepatide's appetite suppression remains intact