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Methods Cell lines, cell culture, xenograft lines, animals, and animal protocols LNCaP, LAPC4 and VCaP cells were purchased from the American Type Culture Collection (ATCC) and cultured in RPMI-1640 medium (for LNCaP) or DMEM (for LAPC4 and VCaP) plus 10% heat-inactivated fetal bovine serum (FBS) and antibiotics

For instance, SOD is known to be inactivated by increased hydrogen peroxide concentration, although its activity may also be reduced by glycosylation of the enzyme and/or loss of copper, an essential cofactor

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10.1208/s12248-021-00628-3 96 GrabruckerA

Despite being a phenolic and poorly soluble compound, curcumin can link with phospholipids (particularly phosphatidylcholine) by forming non-covalent adducts (80)

(123) found that the microbial metabolite p-cresol can inhibit gut hormone expression and regulate small intestinal transit, suggesting its important role in intestinal metabolic regulation